The Tamiami Slasher was the original first main Antagonist in the Dexter novel series. The antagonist Brian Moser from the Dexter TV series is based off of this serial killer. Sometimes also referred to as the Tamiami Trail Killings case, Tamiami Slasher was a serial killer who targeted prostitutes. He is described as resembling Dexter so strongly that, upon seeing an image of Brian with dismembered corpses, Dexter and Deborah are convinced that Dexter is the murderer; when they meet, Dexter notes that Brian is an inch or two taller, thicker through the shoulders and chest, and paler. He first meets Dexter face-to-face in a shipping container located in the same place as the one where their mother was murdered, with Deborah tied up and ready for Dexter to kill. Rather than killing either Deborah or Brian, Dexter lets him go, whereas he kills him in the TV series, recognizing that it is the only way to save his sister. Their professions differ as well; the books have Brian working with imports, while the series has him as a prosthetic surgeon. The age gap between Brian and Dexter is given as one year in the book and two years in the television series. In the books he is known as the Tamiami Slasher; in the show, he is known as the Ice Truck Killer. Brian returns in Dexter is Delicious after learning of the birth of Dexter's daughter. He introduces himself to Dexter's family, and he worked for the cannibalistic coven that would later lure Dexter and Deborah into a trap, later saving them from the cannibals.

He also plays a significant role in the sixth book, Double Dexter.